- Title
- Vitamin D status in pregnant women with asthma and its association with adverse respiratory outcomes during infancy
- Creator
- Jensen, Megan E.; Murphy, V. E.; Gibson, P. G.; Mattes, J.; Camargo, C. A.
- Relation
- Journal of Maternal-Fetal and Neonatal Medicine Vol. 32, Issue 11, p. 1820-1825
- Publisher Link
- http://dx.doi.org/10.1080/14767058.2017.1419176
- Publisher
- Taylor & Francis
- Resource Type
- journal article
- Date
- 2019
- Description
- Background: Vitamin D may influence pregnancy and infant outcomes, especially infant respiratory health. This study aimed to examine vitamin D status in pregnant women with asthma, and whether higher vitamin D levels are associated with fewer adverse respiratory outcomes in their infants. Methods: Pregnant women with asthma, recruited from John Hunter Hospital Newcastle Australia (latitude 33°S), had serum total 25-hydroxyvitamin-D (25(OH)D) measured at 16 and 35 weeks gestation. Infant respiratory outcomes were collected at 12 months by parent-report questionnaire. Mother–infant dyads were grouped by serum 25(OH)D during pregnancy: 25(OH)D < 75 nmol/L (at both time-points) versus 25(OH)D ≥ 75 nmol/L (at one or both time-points). Results: In 52 pregnant women with asthma, mean serum 25(OH)D levels were 61 (range 26–110) nmol/L at 16 weeks, and 65 (range 32–116) nmol/L at 35 weeks, gestation. Thirty-one (60%) women had 25(OH)D < 75 nmol/L at both time-points; 21 (40%) had 25(OH)D ≥ 75 nmol/L at one or both time-points. Maternal 25(OH)D < 75 nmol/L during pregnancy was associated with a higher proportion of infants with “wheeze ever” at 12 months, compared with 25(OH)D ≥ 75 nmol/L (71 versus 43%, p = .04). Infant acute-care presentations (45 versus 13%, p = .02) and oral corticosteroid use (26 versus 4%, p = .03) due to “asthma/wheezing” were higher in the maternal group with 25(OH)D < 75 nmol/L, versus ≥75 nmol/L. Conclusions: Most pregnant women with asthma had low vitamin D status, which persisted across gestation. Low maternal vitamin D status was associated with greater risk of adverse respiratory outcomes in their infants, a group at high risk of developing childhood asthma.
- Subject
- vitamin D; pregnancy; asthma; infant; SDG 3; Sustainable Development Goals
- Identifier
- http://hdl.handle.net/1959.13/1471254
- Identifier
- uon:48625
- Identifier
- ISSN:1476-7058
- Language
- eng
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